A nuclear bone scan, known as bone scintigraphy show high levels of DPD uptake (a cardiac radiotracer)

During a nuclear bone scan, known as bone scintigraphy, patients may
unexpectedly show high levels of DPD uptake (a cardiac radiotracer),
indicating the presence of cardiac amyloidosis.Cardiac amyloidosis (CA) causes the heart to thicken and become inflexible
due to abnormal deposits of protein in place of healthy heart tissue.A DPD scan is an imaging test that helps doctors diagnose CA. It uses a
small amount of a radioactive substance called technetium-99m (99mTc) and
a chemical called DPD.

During the test, these substances are injected into the body and then a
special camera takes pictures of the heart. These images can show if the
heart has abnormal deposits of the amyloid protein.

Amyloid deposits cause the heart muscles to become rigid, which makes it
harder for the heart to pump blood throughout the body. Bone scintigraphy
is therefore used to help doctors see how much amyloid has built up and how
it is affecting the heart.