and metabolic alterations involved in chronic headache onset during the
acute and convalescent periods of post-acute sequelae of the coronavirus
disease 2019.Immunometabolic rewiring in long COVID patients with chronic headache.
COVID-19 patients may experience persistent symptoms, which is often
referred to as post-COVID-19 condition or long COVID. Among the long-term
neurological symptoms, chronic headache is most commonly reported.
In the recent study, researchers evaluate the immuno-metabolomic changes
among long COVID patients experiencing chronic headaches. Blood samples
were obtained between May 2020 to October 2021 from adults with long COVID
[(+)LC]-associated chronic headaches .
Hyperinflammation was involved in triggering the onset of PCC-associated
headache symptoms, with sustained inflammation potentially contributing to
the development of persistent long COVID headaches.
The study findings indicate that chronic generalized inflammation drives
COVID headaches, irrespective of COVID-19 severity. Enhanced glucose
metabolism and inflammation were also observed among PCC headache patients
before headache onset, which likely served as an energy source that
subsequently led to a hyper-inflammatory state.
